"The purpose of this guide is to provide prison and jail administrators and staff with strategies for safely housing inmates at risk of sexual abuse without isolating them. Inmates at risk for sexual victimization-whether identified through screening or victimized in confinement-need protection from abusers, equal access to programming and health and mental health services, and congregate opportunities" (p. 3). Sections of this document include: introduction; a brief look at the use of segregated housing and protective custody in the U.S.; why the use of segregation matters-conditions, impacts, and fiscal costs of isolation; managing people who screen at risk for sexual abuse in general population-incorporating PREA screening requirements into internal classification systems, using case management systems to manage vulnerable inmates, open housing units in general population, mission-specific housing, and key considerations for managing people who screen at risk for sexual abuse in general population; managing particularly high-risk populations-women, youthful inmates, LGBTI (lesbian, gay, bisexual, transgender, and intersex) inmates (e.g., targeted intake and screening, housing and programming placement, monitoring and safety, and commitment and training); and conclusion.